Daptomycin (Intravenous route)



Brand Names:

  • Cubicin
  • Cubicin RF

Dosage Forms:

  • Powder for Solution




Uses of This Medicine:

Daptomycin injection is used to treat complicated skin and skin structure infections (cSSSI). It is also used to treat infections in the bloodstream, including right-sided infective endocarditis.

Daptomycin belongs to the class of medicines known as antibiotics. It works by killing bacteria or preventing their growth. However, this medicine will not work for colds, flu, or other virus infections.

This medicine is available only with your doctor's prescription.

Before Using This Medicine:

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:


Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.


Appropriate studies performed to date have not demonstrated pediatric-specific problems that would limit the usefulness of daptomycin injection to treat cSSSI in children. However, safety and efficacy have not been established in children with cSSSI younger than 1 year of age, and in children with infections in the bloodstream.

Older adults—

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of daptomycin injection in the elderly. However, elderly patients are more likely to have increased unwanted side effects, which may require caution in patients receiving daptomycin injection.


Pregnancy CategoryExplanation
All TrimestersBAnimal studies have revealed no evidence of harm to the fetus, however, there are no adequate studies in pregnant women OR animal studies have shown an adverse effect, but adequate studies in pregnant women have failed to demonstrate a risk to the fetus.


There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Other medicines—

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are receiving this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Atorvastatin
  • Fluvastatin
  • Lovastatin
  • Pravastatin
  • Rosuvastatin
  • Simvastatin

Other interactions—

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other medical problems—

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

  • Diarrhea or
  • Muscle problems (eg, myopathy, rhabdomyolysis) or
  • Nerve problems (eg, neuropathy)—Use with caution. May make these conditions worse.
  • Kidney disease—Use with caution. The effects may be increased because of slower removal of the medicine from the body.
  • Staphylococcus infection, persisting or relapsing—Patients with this condition should have repeated blood tests.

Proper Use of This Medicine:

A nurse or other trained health professional will give you this medicine. This medicine is given through a needle placed in one of your veins. This medicine is given slowly, so the needle will remain in place for about 2 minutes or 30 minutes.

To help clear up your infection completely, keep using this medicine for the full time of treatment, even if you begin to feel better after a few days. Also, this medicine works best when there is a constant amount in the blood. To help keep the amount constant, you must receive this medicine on a regular schedule.

Precautions While Using This Medicine:

Your doctor will check your progress closely while you are receiving this medicine. This will allow your doctor to see if the medicine is working properly and to decide if you should continue to receive it.

If your symptoms do not improve within a few days or if they become worse, check with your doctor.

This medicine may cause serious allergic reactions, including anaphylaxis. Anaphylaxis can be life-threatening and requires immediate medical attention. Call your doctor right away if you have a rash, itching, trouble breathing, trouble swallowing, or any swelling of your hands, face, or mouth while you are using this medicine.

Call your doctor right away if you develop chest pain, dry cough, fever, general feeling of tiredness or weakness, rapid breathing, trouble breathing, or skin rash after receiving this medicine. These maybe symptoms of a serious condition called eosinophilic pneumonia.

Daptomycin injection may cause diarrhea, and in some cases it can be severe. It may occur 2 months or more after you stop receiving this medicine. Do not take any medicine to treat diarrhea without first checking with your doctor. If you have any questions or if mild diarrhea continues or gets worse, check with your doctor.

If you have unexplained muscle pain, tenderness, or weakness while receiving this medicine, check with your doctor right away.

Check with your doctor right away if you are having burning, numbness, tingling, or painful sensations in the arms, hands, legs, or feet after receiving this medicine. These could be symptoms of a condition called peripheral neuropathy.

Before you have any medical tests, tell the medical doctor in charge that you are receiving this medicine. The results of some tests may be affected by this medicine.

Do not take other medicines unless they have been discussed with your doctor. This especially includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

Side Effects of This Medicine:

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

More common
Bloating or swelling of the face, arms, hands, lower legs, or feet
rapid weight gain
tingling of the hands or feet
unusual weight gain or loss
Less common
Abdominal or stomach pain
black, tarry stools
bladder pain
bloody or cloudy urine
blurred vision
chest pain or discomfort
decreased frequency or amount of urine
decreased urine output
difficult or labored breathing
difficult, burning, or painful urination
dilated neck veins
dry mouth
extreme fatigue
faintness or lightheadedness when getting up suddenly from a lying or sitting position
fast heartbeat
frequent urge to urinate
increased blood pressure
increased thirst
irregular breathing
irregular heartbeat
itching in the genital or other skin areas
itching, pain, redness, swelling, tenderness, or warmth on the skin
loss of appetite
lower back or side pain
mood changes
muscle pain or cramps
muscle twitching
numbness or tingling in the hands, feet, or lips
pale skin
pounding in the ears
rapid weight gain
rapid, shallow breathing
slow or fast heartbeat
sore throat
swelling of the face, fingers, ankles, or hands
tightness in the chest
troubled breathing with exertion
unusual bleeding or bruising
usual tiredness or weakness
vomiting of blood or material that looks like coffee grounds
weight gain
Bleeding gums
blood in the urine or stools
burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
clay-colored stools
dark urine
difficulty with moving
eye pain
feeling of warmth
feeling unusually cold
general feeling of illness
hives, itching, or rash
increase in bone pain
joint pain, stiffness, or swelling
loss of appetite
mood or mental changes
muscle aching or cramping
muscle spasms (tetany) or twitching
no blood pressure or pulse
pain in the joints
pinpoint red spots on the skin
rapid or irregular heartbeat
redness of the face, neck, arms, and occasionally, upper chest
redness of the skin
redness, blistering, peeling, or loosening of the skin
skin rash, encrusted, scaly and oozing
sore throat
sores, ulcers, or white spots on the lips or in the mouth
stopping of heart
swelling of the eyelids, face, lips, hands, or feet
swollen glands
swollen joints
swollen, painful, or tender lymph glands in the neck, armpit, or groin
troubled breathing or swallowing
twitching, twisting, uncontrolled repetitive movements of the tongue, lips, face, arms, or legs
unpleasant breath odor
unusual bleeding or bruising
vomiting of blood
yellow eyes or skin
Incidence not known
Abdominal or stomach cramps
abdominal or stomach tenderness
diarrhea, watery, and severe, which may also be bloody
difficulty with swallowing
dry cough
puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
unusual weight loss

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common
Bleeding, blistering, burning, coldness, discoloration of the skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the injection site
diarrhea, mild
difficulty having a bowel movement (stool)
Less common
back pain
blurred vision
cold sweats
cool, pale skin
decreased appetite
flushed, dry skin
fruit-like breath odor
increased hunger
increased urination
itching of the vagina or outside genitals
lack or loss of strength
limb pain
pain during sexual intercourse
slurred speech
thick, white, curd-like vaginal discharge without odor or with mild odor
trouble sleeping
unexplained weight loss
Acid or sour stomach
bad, unusual, or unpleasant (after) taste
change in taste
continuing ringing or buzzing or other unexplained noise in the ears
excess air or gas in the stomach or intestines
feeling of constant movement of self or surroundings
full feeling
hearing loss
pain or discomfort in the chest, upper stomach, or throat
passing gas
pressure in the stomach
red, sore eyes
seeing, hearing, or feeling things that are not there
sensation of spinning
sore mouth or tongue
swelling of the abdominal or stomach area
swelling or inflammation of the mouth
white patches in the mouth or on the tongue

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

Last Updated: 9/4/2017
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